Bis (Diamines) Cu and Zn Complexes of Flurbiprofen as Potential Cholinesterase Inhibitors: In Vitro Studies and Docking Simulations

Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between nerve cells reducing risk of dementia. In an effort treat disease, we synthesized flurbiprofen-based diamines (1,2 diaminoethane 1,3 diaminopropane) Zn(II), Cu(II) metal complexes characterized them single-crystal X-ray analysis, NMR, (FT)-IR, UV-Vis, magnetic susceptibility, elemental analysis conductivities measurements. Synthesized diamine appeared in ionic forms have distorted octahedral geometry based on conductivity studies, susceptibility electronic studies. Single crystal diffraction confirmed (2b) Cu(H2O)2(L1)2(L2)2 complex formation. Moreover, tested all against cholinesterase enzyme that showed higher inhibition potential. general, copper inhibitory activities than simple with flurbiprofen. These may derive more effective safe for cholinesterases.